Swine Flu 2009 Outbreak -- Sequence information from CDC

This is the general structure of  an influenza A virion. You can reference the corresponding functions for the abbreviations (PB2, PB1, PA, HA, NP, NA, NS) used in following table from CDC.

 

The following swine influenza A (H1N1) sequences were submitted to NCBI and are available in GenBank:

April 27, 2009, submitted by CDC:

	PB2	PB1	PA	HA	NP	NA	MP	NS
Influenza A virus (A/California/04/2009(H1N1))	FJ966079	FJ966080	FJ966081	FJ966082	FJ966083	FJ966084	FJ966085	FJ966086
Influenza A virus (A/California/05/2009(H1N1))	FJ966955	FJ966958	FJ966957	FJ966952	FJ966953	FJ966956	FJ966954
Influenza A virus (A/California/06/2009(H1N1))	FJ966963	FJ966965	FJ966964	FJ966960	FJ966961		FJ966962
Influenza A virus (A/California/07/2009(H1N1))	FJ966976	FJ966978	FJ966977	FJ966974			FJ966975
Influenza A virus (A/California/09/2009(H1N1))				FJ966971		FJ966973	FJ966972
Influenza A virus (A/Texas/04/2009(H1N1))				FJ966982	FJ966979	FJ966981	FJ966983
Influenza A virus (A/Texas/05/2009(H1N1))			FJ966970	FJ966959	FJ966967	FJ966969	FJ966968	FJ966966

You can find more information by clicking following website:

 

In fact, CDC has pointed this out in an article "Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008." published on Antimicribial Agents and Chemotherapy, September 2008, p. 3284-3292, Vol. 52, No. 9.

Following is a table for characterization of extreme and mild outliers among A(H1N1) viruses from past seasons in 2007:

TABLE 3. Characterization of extreme and mild outliers among A(H1N1) viruses from three previous seasons^a

Season Strain Mean IC50 ± SDc (nM) Outlier(s)/drug(s)d NA mutation(s)e Accession no. Oseltamivir Zanamivir 2005-2006 A/Zhejiang/Xiangshan522/2006b 131.85 ± 31.55 2.56 ± 0.01 E/O H274Y EU879082 2006-2007 A/Georgia/20/2006b 383.01 ± 143.69f 2.55 ± 1.02 E/O H274Y EU516197i 2006-2007 A/Massachusetts/5/2007b 258.48 ± 41.56g 1.71 ± 0.28 E/O H274Y EU516028 2006-2007 A/Texas/31/2007b 285.56 ± 18.05 1.14 ± 0.33 E/O H274Y EU516027 2006-2007 A/Minnesota/23/2007b 225.61 ± 13.85 0.99 ± 0.05 E/O H274Y EU516141 2006-2007 A/Gansu/Chenguan/1129/2007b 126.89 ± 1.96 0.49 ± 0.25 E/O H274Y EU879064 2005-2006 A/Guangdongluohu/1232/2006 8.76 ± 4.68 2.33 ± 1.47 M/O D79G, S247G EU879081 2006-2007 A/Hubei/Jiangan/1251/2006 6.75 ± 5.24 13.50 ± 12.24 M/Z, M/O H126N EU879078 2006-2007 A/Thailand/708/2006 4.51 ± 1.36 2.76 ± 0.01h M/O None EU879083 2005-2006 A/Zhejiang/Xiaocheng/1345/2006 4.21 ± 0.68 0.54 ± 0.12 M/O S247G EU879079 2005-2006 A/Thailand/674/2006 1.95 ± 0.69 7.12 ± 3.64 M/Z G248R EU879080

^a Includes viruses collected from 1 October 2004 to 30 September 2007.

^b Resistant virus.

^c Mean IC₅₀ ± SD values were calculated from data collected from at least three independent experiments.

^d E, extreme; M, mild; O, oseltamivir (IC₅₀s > 2.89 nM); Z, zanamivir (IC₅₀s > 3.89 nM).

^e Boldface type indicates a mutation in the NA active site.

^f A 638-fold increase in the IC₅₀ for oseltamivir compared to that of the matching virus A/Georgia/17/2006 (accession no. EU100630).

^g A 1,616-fold increase in IC₅₀ for oseltamivir compared to that of the matching virus A/Massachusetts/6/2006 (accession no. EU100634).

^h IC₅₀s were below the cutoff after retesting.

ⁱ Additional sequences for this virus are those of accession no. EU516198 and EU516199.

 

H247Y is quite resistant to Roche's Tamiflu (oseltamivir phosphate). I am not very sure if the strain found in Mexico with the same mutation H247Y. However, the news from the World Health Organization seems good for us, and, of course, for Roche...........“The information we have to far is the strain is receptive to Tamiflu,” WHO spokesman Aphaluck Bhatiasevi told Dow Jones Newswires.