(轉載) 翹翹板

很有道理不是嗎？給原創作者拍拍手吧！

暗黑版結局~~

原出處：粉紅兔子窩

 

生技公司未來的新商業模式：獨立生存、長期營運

Mass. biotech firms urged to remain independent

 

By Robert Weisman       Globe Staff / October 7, 2009

It’s time for pulling up the bootstraps.

That was the message delivered to biotechnology start-ups at the 11th annual MassBio Investors Forum yesterday. At a time when major drug makers are consolidating and may be less willing to buy fledgling companies, biotechs have to make it on their own and bring drugs to market themselves.

Industry leaders warned that the old model of forming a biotech company, shepherding a drug through development and years of clinical trials, and then selling the company to a pharmaceutical buyer may be played out.

Success will now require a survival mentality and a focus on remaining independent, said Barry Greene, president of Cambridge biotech Alnylam Pharmaceuticals Inc.

“Cultures that depend on survival are absolutely critical for this industry to succeed,’’ Greene said. “If you don’t want to [stay independent], you’re not a company. You’re a project.’’

Biotech leaders said it could take seven to 10 years to bring new drugs into commercial use in the future, compared with the five- to six-year time horizon of the past, mostly because of scarcer financing and a longer government approval process.

James J. O’Mara, vice president of business development at another Cambridge biotech, Ironwood Pharmaceuticals Inc., said more start-ups are willing to invest in technology without the expectation they will be snapped up for a premium. If the technology doesn’t lead to a product, they must be ready to shut down and cut their losses, he said. “People are being much more explicit about the company they’re building, and I think that’s a good thing,’’ O’Mara said.

During a panel on building a sustainable biotech business model, moderator Ted Torphy, chief scientific officer and head of external research for Johnson & Johnson Pharmaceuticals, told the audience at the Sheraton Boston Hotel that drug companies continue to look to biotechs for research and development.

“As an industry, we’re spending more and more for less and less productivity,’’ Torphy conceded. “Unless this changes, large pharmaceutical companies may be doing better by their shareholders if they invest in oil rather than investing in drug discovery.’’

But that doesn’t mean they are as ea ger to make acquisitions as they’ve been in the past, Torphy said, noting that big pharmaceutical companies have been moving aggressively to pare costs by streamlining research and striking partnerships with biotechs. “We want products, we don’t want companies,’’ he said.

Not everyone agreed the old business model is broken.

Alan Crane, former chief executive of Momenta Pharmaceuticals in Cambridge who is now general partner at Polaris Venture Partners in Waltham, said biotechs that focus on developing “breakthrough technology’’ rather than finding new ways to use old technology will get funding despite the retrenchment at pharmaceutical companies.

“There’s a lot of reason for long-term optimism,’’ Crane said, citing the aging of the population and growth in global markets.

The most successful companies will be innovators, said Katrine Bosley, chief executive of Avila Therapeutics in Waltham .

“One way you know that you’re innovating is if everybody thinks you’re crazy,’’ Bosley said. “If you’re not getting that kind of reaction on a regular basis, then you’re not being innovative enough.’’

But in the near future, biotechs will operate in an environment of funding scarcity and will need to adjust their goals - and their “burn rates,’’ the speed at which they run through venture capital - said Noubar Afeyan, managing partner and chief executive of Flagship Ventures in Cambridge.

He defended venture capital firms’ practice of investing in more mature companies, which has come under criticism from cash-starved entrepreneurs. “If we pour a lot of money into the early stage, we’re going to have a lot of orphan companies.’’

 

媽媽歌

天啊！跟我每天對著小孩碎碎念的內容幾乎一樣..........................

It's so touching!

腳步加速的那一秒，牠知道................最愛牠的人回來了。What is love? This lion can tell you.



上面的連結已失效，請參考下面連結：(2013-06-18更新)

涅槃 (Nirvana)

一段不可思議的涅槃(Nirvana)與極樂(Euphoria)的體驗。是否達到涅槃與極樂其實意味著以意識抑制左腦的運作，並讓右腦徹底控制一切的一種感覺？

**************************************************************************************

你腦內的兩個世界(中文) -- 吉兒泰勒(Jill Bolte Taylor)

諾亞方舟

記得幾年前我為了應徵工作飛到美國去給演講時，在最後一張slide我把台灣用動畫放了上去，說明台灣在支援國際生技公司新藥開發方面的人才優勢，當台灣從畫面上蹦出來時，在場的人都笑了：小小一個台灣怎麼"長大"了？我站在台上心想：台灣的土地面積或許不大，但是台灣人才腦子裡可以構築的天地卻不可小歔！演講後心裡有一些悸動........哪一天.....要到哪一天台灣才有像樣的生技公司可以證明我的slide？

前幾天剛好有空，去看了一下台灣自有品牌的LUXGEN MPV，雖然是試裝車，品質還未臻完善，但是看到台灣自己的汽車廠牌的mark，心裡還是有些悸動.......就像我多年前在美國演講後的悸動一樣。希望這個品牌能成長茁壯，證明台灣人可以驕傲的選擇台灣人自己製造的車子。

今天看到下面這個影片，雖說沙畫早已不是什麼新鮮的玩意兒，但是影片裡所展現出台灣的動物園在自我推介時所展現的自我風格，那種微微的悸動又出現了.......

 

展現對自我的信心是傳達這種心靈悸動的必要元素。台灣人該對自己有信心，我們已經在很多領域攻城掠地、展現世界級的競爭力。當許許多多不同行業都出現台灣品牌的世界級企業，或許有助於在臺灣的人拓展心胸與度量，走出狹隘的地域情結，專注於向外對付各自領域的國際競爭對手，而無須再向內自相殘殺。

真神曲也

 

jeanny翻成閩南語的七仔，整首能翻唱翻到這樣也算是厲害了。

 

本土檳榔翻唱版：施文彬 -- 七仔

施文彬 - 七仔
作詞：武雄 / 作曲：佚名 / 編曲：屠穎    
 女主播：張雅芳（華人商業台主播） 
 男記者：蘇欣偉（東森新聞台記者） 
  
 七仔.........七仔......... 
  
 （女主播）： 
 首先是國內新聞，今天晚上六點，有一名男子爬到台北三月星光大樓頂樓， 
 不斷發出大聲嘶吼並有跳樓傾向，由於正值下班時間，民眾的圍觀， 
 頓時造成交通癱瘓，目前警方與消防隊已經到達現場， 
 馬上透過 SNG 連線，帶您進一步瞭解到現場最新狀況。 
  
 七仔......... 
  
 （男記者）： 
 是的，現在記者身後就是【三越星光大樓】，根據附近民眾表示： 
 今天晚上五點多發現一名男子在頂樓徘徊，並大聲嘶吼有跳樓的跡象， 
 目前警方已經封鎖現場，並派遣談判專家潛入大樓。根據本記者獨家消息指出， 
 該名男子並無固定職業，且經常出現於各類示威遊行， 
 因此記者初步研判他這次跳樓的動機———不排除有政治因素——。 
  
 七仔.........七仔......... 
  
 （o s）： 
 七仔，搭！你看，頭前遐就是咱當初熟識的新公園啦， 
 現主時，也已經是改做【二二八紀念公園】囉，真想袂到， 
 想袂到這個時代的改變，就親像你對我的欺騙。你對我欺騙啦.........唉......... 
  
 你敢袂記哩彼暗，也就是咱初初約會彼暗， 
 咱對著公園內已經沒水的魚池仔有詛咒，講誰人若變心， 
 就會親像撈起來疊咧魚池仔邊，去乎人毒死的魚仔共款， 
 共款會死甲真歹看啦.......你敢攏袂記咧！？？？ 
  
 七仔　你斟酌看　七仔　我咧樓尾頂啦　你講你上愛我　但是又擱變卦　違背咱的詛咒 
 七仔　你斟酌看　七仔　我咧樓尾頂啦　卡緊出來談判　代誌大家講破　若無我無愛活 
 啊.......啊........ 
  
 （o s）： 
 我會記咧阿扁仔嘟當選彼年，有一天透早， 
 你講你想欲去總統府頭前看人【升旗】，我也用歐兜醜在你去到遐， 
 結果還未唱國歌，就去乎交通仔開一張紅單，但是，但是咱攏真歡喜不是呢？者， 
 你看，這嘛介壽路已經改做【凱達格蘭大道】， 
 歐兜醜嘛會使住對面走，就親像你嘛跟人走共款啦。 
  
 記咧彼工你有親嘴講過，講若想欲甲你結成夫妻， 
 就愛有才調先做頭家，我以為彼是你對我的鼓勵， 
 誰知影就在民國 85 年 5 月 20 日阿輝仔【宣誓就職】彼工， 
 全台灣 2100 萬人攏是頭家啦，你講，你欲嫁都一個，你講啊！你講啊，你講啊！........... 
  
 七仔　你真愛死炸　七仔　我歸腹火啦 
 叫我怎樣饒赦　女性的可怕　你害我　心痛疼 
 七仔　你不免講啦　七仔　世間無咧坎蓋 
 到這已經看破　跳落上快活　是命運是註定 
 啊.......啊........ 
  
 （女主播）： 
 【本台消息】發生在今晚【三月星光大樓】企圖跳樓的男子， 
 目前仍然與警方僵持不下，根據證實這只是一件單純的【殉情事件】， 
 但由於該名男子並無進一步的具體行動，現場已引起圍觀群眾的鼓譟與不滿， 
 警方呼籲全體市民及流動攤販不要再前往該地， 
 並希望這名男子的女友〔七仔〕能夠儘速趕到現場協助警方處理。 
  
 七仔.......啊........為何你猶原無出現啦...... 
 七仔　我咧樓尾頂啦　七仔　七仔　七仔 
 我已經看破　你騙人的詛咒　依依難捨嘛是無卡詛 
 七仔　你敢有咧看　七仔　我咧樓尾頂啦 
 對你所有的情愛　最後的審判　是運命　是註定 
 七仔.........七仔　七仔　七仔　啊..........  
 

經典原唱版：falco - jeanny

Jeanny, komm, come on
Steh auf - bitte, du wirst ganz naß
Schon spät, komm - wir müssen weg hier,
raus aus dem Wald, verstehst du nicht?
Wo ist dein Schuh, du hast ihn verloren,
als ich dir den Weg zeigen mußte
Wer hat verloren? Du dich?
Ich mich? Oder, oder wir uns?

Jeanny, quit livin' on dreams
Jeanny, life is not what it seems
Such a lonely little girl in a cold, cold world
There's someone who needs you
Jeanny, quit livin' on dreams
Jeanny, life is not what it seems
You're lost in the night, don't wanna struggle and fight
There's someone, who needs you, babe

Es ist kalt, wir müssen weg hier, komm
Dein Lippenstift ist verwischt
Du hast ihn gekauft und ich habe es gesehen
Zuviel rot auf deinen Lippen und du hast gesagt:
"Mach mich nicht an"
Aber du warst durchschaut, Augen sagen mehr als Worte
Du brauchst mich doch, hmh?
Alle wissen, daß wir zusammen sind ab heute,
jetzt hör ich sie! Sie kommen
Sie kommen, dich zu holen
Sie werden dich nicht finden
Niemand wird dich finden, du bist bei mir

Jeanny, quit livin' on dreams
Jeanny, life is not what it seems
Such a lonely little girl in a cold, cold world
There's someone who needs you
Jeanny, quit livin' on dreams
Jeanny, life is not what it seems
You're lost in the night, don't wanna struggle and fight
There's someone, who needs you

Newsflash: In den letzten Monaten
ist die Zahl der vermißten Personen
dramatisch angestiegen. Die jüngste
Veröffentlichung der lokalen
Polizeibehörde berichtet von einem
weiteren tragischen Fall. Es handelt
sich um ein neunzehnjähriges
Mädchen, das zuletzt vor vierzehn
Tagen gesehen wurde. Die Polizei
schließt die Möglichkeit nicht aus, daß
es sich hier um ein Verbrechen handelt.

Jeanny, quit livin' on dreams
Jeanny, life is not what it seems
Such a lonely little girl in a cold, cold world
There's someone who needs you
Jeanny, quit livin' on dreams
Jeanny, life is not what it seems
You're lost in the night, don't wanna struggle and fight
There's someone, who needs you